Bruce Given

Dr. Given is CEO of Leonardo Biosystems, serves as a Healthcare Products Consultant as the Principal of Bruce Given Consulting and is Chairman of the Board for ICON, plc. (Nasdaq: ICLR). Until June of 2007, Dr. Given served as President and Chief Executive Officer and as a member of the Board of Directors of Encysive Pharmaceuticals, which he joined in 2002. Prior to joining Encysive Pharmaceuticals, he was with Johnson & Johnson for 9 years, serving in several capacities including as President, International, Ortho-Clinical Diagnostics and as Group Vice President, Head of U.S. Marketing & Sales, Research & Development for Janssen Pharmaceutica.

He has held various executive and senior management positions at Sandoz Pharma Ltd., Sandoz Research Institute and Schering-Plough Corporation. Prior to entering the pharmaceutical industry, he was on the medical faculty at the University of Chicago.

n addition to his work with Leonardo and ICON, Dr.Given serves on the Boards of Directors for Calando Pharmaceuticals, for BioHouston, where he is Secretary of the Executive Committee of the Board and the Texas Life Science Center. He is a member of the CPRIT Commercialization Committee, a member of the inCube Scientific Advisory Board, served on the Technology Review Committee of MD Anderson Medical Center, and is past Chairman of the Rider University Scientific Advisory Board.