Biomaterials & Coatings

Biomaterials play a critical role in the use and function of both implantable and non-implantable interventional devices. For instance, slow eluting Dexamethasone coatings are routinely used in pacemaker leads to reduce local inflammation caused by foreign body reaction, as well as to reduce fibrous encapsulation of electrodes resulting in lower impedance. The drug eluting stent is another example of a drug eluting coating on the surface of the stent that reduces smooth muscle cell proliferation.

In other applications, we use hydrophilic coatings on certain interventional catheters to reduce problems associated with friction when these devices are used clinically, or heparin coatings to make vascular devices more blood compatible.

More recently, we have begun to apply unique extracellular matrix proteins to the surfaces of vascular devices and certain sensors to promote cell adhesion and suppress immunoreaction.